I did my Master's Degree online.  It was a fairly good deal--I could do schoolwork at all sorts of crazy hours of the day or night.  I could work overtime and skip a day, then make it all up the next day.  I could sometimes schedule my schoolwork for my "prime time" hours, which are early evening hours when I am still able to focus and put in the effort to learn.

What I did have a problem with was family members.  Your friends and your family tend to believe that when you are physically present in the home, you are not busy.  I found that I really had to fight hard for my schooling time, and I have to fight for my work time as well.

When you trade having a boss standing over you to make sure you are doing work, the boss doesn't go away.  He (or she) just moves inside of you.  You have to be the one that makes sure you do all the work you need to do, even taking a some extra  time now and then to finish a project.  In this task, your family members will naturally be your opponents.

I have found that I can get them to leave me alone for several hours if I am flexible about when those hours need to be taken.  If Billy has a soccer game to go to, you're going to have to drive him there, even if it means that you either get up earlier and get ahead on your work, or you come back afterward and work late to catch up.

It gets a little hairier if you have two or more home-workers in the house.  You have to try to work around the same times, with no chit chat during those hours.  Otherwise, you find that you have all been in the home for months without saying much more than "good morning" and "good night."

Younger children and pets require more flexibility.  If Rover needs to go out, let him out now. It is far better than making him wait and having to clean up behind him.  Same for small children.  If Jasmine needs to eat, feed her.  If you are in the middle of a project that cannot wait for a  long interruption, give her some crackers to snack on for a while.  Then, as soon as you can, go feed your child.

Another thing that can help is schedule breaks for the most regular interruptions.

Finally, realize that there is no perfect world.  Johnny will call at 3:15 PM, saying that he needs you to pick him up from the high school and take him across town for drama practice.  No matter how often you tell him that you are working and can not stop to be his taxi, he will call for his ride.  He's in high school and can not understand why he needs to avoid interrupting your work, no matter how often you tell him the reasons.   If you can take a break and be there, waiting, you will skip some unneeded frustration on both your part and Johnny's.